at Georgetown University
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about what we do
We are interested in the cell biology of membrane traffic, cell wall biosynthesis,
and ion homeostasis, and how these three processes are inter-related. We study
these processes in two related species of fungi, the model organism Saccharomyces
cerevisiae and a closely related opportunistic human pathogen, Candida glabrata.
Our overall goal is to determine how these three processes compare and contrast
between the two species in order to understand why one is free-living and the
other is a pathogen. Specific projects take advantage of genetics, molecular biology,
biochemistry and bioinformatics.
Current Projects and Publications
Co-director, major in biology of global health
Ph.D. (1989) The Johns Hopkins University, Biochemistry
B.A. (1982) Hood College, Biochemistry
Ph.D. (2011) Biology, Georgia Institute of Technology
M.S. (2006) Bioinformatics, Georgia State University
M.S. (2001) Biochemistry, University of Mumbai
B.A. (1999)Chemistry (Hons.), University of Mumbai
Currently studying open-reading frames (ORFs) in the yeast genome that overlap ORFs on the opposite DNA strand
Studying the role of a GTP-binding protein in autophagy (self-eating) in Saccharomyces.
Studying GEA2/Vma proteins in Candida glabrata.
Horizontal gene transfer between bacteria and the phages (viruses) that prey on them.
Annotation of Drosophila genes.